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Selamectin[220119-17-5] for cats dogs rabbits

Suzhou Pharmaceutical supplies Selamectin bulk active pharmaceutical ingredient (API) to the pharmaceutical industry. Our Selamectin is manufactured by cGMP compliant facility. Welcome to contact us for further details including current DMF status for the product and up to date regulatory status of the manufacturing facility. We look forward to assisting you with your research and development projects.

What is Selamectin?

Selamectin (trade names Revolution, Stronghold) is a topical parasiticide and antihelminthic used on dogs and cats, distributed by Pfizer.[1] It treats and prevents infections of heartworms, fleas, ear mites, sarcoptic mange (scabies), and certain types of ticks in dogs, and prevents heartworms, fleas, ear mites, hookworms, and roundworms in cats. Selamectin is not approved for human use.


The drug is applied topically. It is waterfast, and does not lose its effectiveness with bathing. It is packaged according to its varying dosage sizes, and is applied once monthly.

Mode of action

Selamectin disables parasites by replacing glutamate in their muscle synapses; glutamate is the amino acid which normally interacts with the receptors that open chloride channels into the muscle. Selamectin interferes with this process; it activates the chloride current without desensitization, allowing chloride ions to enter the nerve cells and causing neuromuscular paralysis, impaired muscular contraction, and eventual death.

The substance fights both internal and surface parasitic infection. Absorbed into the body through the skin and hair follicles, it travels through the bloodstream, intestines, and sebaceous glands; parasites ingest the drug when they feed on the animal’s blood.

Side effects

Selamectin has been found to be safe and effective in a 2003 review.[2]
Selamectin has high safety ratings, with less than 1% of pets displaying side effects. In cases where side effects do occur, they most often include passing irritation or hair loss at the application site

. Symptoms beyond these (such as drooling, rapid breathing, lack of coordination, vomiting, or diarrhea) could indicate the existence of a serious underlying cause, requiring immediate veterinary care.

Similar products

Main rival products for dogs include ivermectin (trade names Stromectol, Ivermec and others) or milbemycin oxime (Interceptor) for heartworms, fipronil (Frontline) or lufenuron (Program) for fleas, or the combination milbemycin oxime/lufenuron (Sentinel) for both.

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