the treatment of acute myeloid leukemia
midostaurin, sold under the brand name rydapt, is a multi-targeted protein kinase inhibitor that has been investigated for the treatment of acute myeloid leukemia (aml), myelodysplastic syndrome (mds) and advanced systemic mastocytosis. it is a semi-synthetic derivative of staurosporine, an alkaloid from the bacterium streptomyces staurosporeus.
the u.s. food and drug administration (fda) considers it to be a first-in-class medication.
aml and mds
midostaurin was found to be active against oncogenic cd135 (fms-like tyrosine kinase 3 receptor, flt3), in preclinical studies. clinical trials have primarily focused on relapsed/refractory aml and mds and have included single agent and combinati
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