treatment for major depressive disorder
nsi-189 is an experimental, potential antidepressant that is under investigation by neuralstem, inc. for the treatment for major depressive disorder (mdd), as well as for cognitive impairment and neurodegeneration.
a phase ii clinical trial for mdd failed to meet the primary depression endpoint (madrs) in july 2017, although statistically significant improvements have been reported on a number of secondary depression and cognition endpoints.
the compound's activity was discovered using phenotypic screening with a library of 10,269 compounds to identify compounds that promoted neurogenesis in vitro. as of 2016 the target of the compound was unknown but it appeared to promote neurogenesis in
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